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SMILES: CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cc1)C1CC1

InChI Key: InChIKey=CYIHFXFWPCSXOH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188789   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188789
PNG
(US9169260, 55)
Show SMILES CC(C)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cc1)C1CC1
Show InChI InChI=1S/C27H31N7O/c1-18(2)32-14-10-21(11-15-32)24-16-25(30-27(35)23-17-29-33-13-3-12-28-26(23)33)34(31-24)22-8-6-20(7-9-22)19-4-5-19/h3,6-9,12-13,16-19,21H,4-5,10-11,14-15H2,1-2H3,(H,30,35)
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Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair