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BDBM188793 US9169260, 59

SMILES: Cc1ccc(c(F)c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC1

InChI Key: InChIKey=AFXNVZPZBFFDTC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188793   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM188793
PNG
(US9169260, 59)
Show SMILES Cc1ccc(c(F)c1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CCC1
Show InChI InChI=1S/C26H28FN7O/c1-17-6-7-23(21(27)14-17)34-24(30-26(35)20-16-29-33-11-3-10-28-25(20)33)15-22(31-34)18-8-12-32(13-9-18)19-4-2-5-19/h3,6-7,10-11,14-16,18-19H,2,4-5,8-9,12-13H2,1H3,(H,30,35)
PDB
MMDB

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Similars

US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...


US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair