BDBM188823 US9169260, 89

SMILES: Fc1cc(ccc1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CN(C1)C1CCC1)C1CC1

InChI Key: InChIKey=OPMIVRFIXVCXJC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188823   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM188823 (US9169260, 89) Show SMILES Fc1cc(ccc1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CN(C1)C1CCC1)C1CC1 Show InChI InChI=1S/C26H26FN7O/c27-21-11-17(16-5-6-16)7-8-23(21)34-24(12-22(31-34)18-14-32(15-18)19-3-1-4-19)30-26(35)20-13-29-33-10-2-9-28-25(20)33/h2,7-13,16,18-19H,1,3-6,14-15H2,(H,30,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.2	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...				US Patent US9169260 (2015) BindingDB Entry DOI: 10.7270/Q26H4G6N
					More data for this Ligand-Target Pair