BDBM188848 US9169260, 114

SMILES: CCN(CC)CCC(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cc(Br)cnc23)n(n1)-c1ccc(C)cc1

InChI Key: InChIKey=RUQWXDGDBYGUMS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188848   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM188848 (US9169260, 114) Show SMILES CCN(CC)CCC(=O)N1CCC(CC1)c1cc(NC(=O)c2cnn3cc(Br)cnc23)n(n1)-c1ccc(C)cc1 Show InChI InChI=1S/C29H35BrN8O2/c1-4-35(5-2)13-12-27(39)36-14-10-21(11-15-36)25-16-26(38(34-25)23-8-6-20(3)7-9-23)33-29(40)24-18-32-37-19-22(30)17-31-28(24)37/h6-9,16-19,21H,4-5,10-15H2,1-3H3,(H,33,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.2	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...				US Patent US9169260 (2015) BindingDB Entry DOI: 10.7270/Q26H4G6N
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