BDBM188919 US9169260, 185

SMILES: Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCC(N)CC1

InChI Key: InChIKey=WHZCYCSTYPFOOA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188919   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM188919 (US9169260, 185) Show SMILES Cc1ccc(nc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCC(N)CC1 |(6.33,5.23,;5.24,4.14,;3.75,4.54,;2.66,3.45,;3.06,1.96,;4.55,1.56,;5.64,2.65,;1.97,.87,;1.97,-.67,;.51,-1.14,;-.4,.1,;.51,1.35,;.11,2.84,;-1.38,3.24,;-2.47,2.15,;-1.78,4.72,;-1.3,6.19,;-2.55,7.09,;-3.79,6.19,;-5.3,6.51,;-6.33,5.36,;-5.85,3.9,;-4.35,3.58,;-3.32,4.72,;.11,-2.63,;-1.38,-3.03,;-1.78,-4.52,;-.69,-5.61,;-1.09,-7.09,;.8,-5.21,;1.2,-3.72,)| Show InChI InChI=1S/C22H24N8O/c1-14-3-8-19(25-12-14)30-20(11-18(28-30)15-4-6-16(23)7-5-15)27-22(31)17-13-26-29-10-2-9-24-21(17)29/h2-3,8-13,15-16H,4-7,23H2,1H3,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.2	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...				US Patent US9169260 (2015) BindingDB Entry DOI: 10.7270/Q26H4G6N
					More data for this Ligand-Target Pair