BDBM188932 US9169260, 198

SMILES: CN1CCN(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1

InChI Key: InChIKey=CBGMVWLOYGVWSO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 188932   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM188932 (US9169260, 198) Show SMILES CN1CCN(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1 Show InChI InChI=1S/C21H23N9O/c1-15-4-5-17(23-13-15)30-18(12-19(26-30)28-10-8-27(2)9-11-28)25-21(31)16-14-24-29-7-3-6-22-20(16)29/h3-7,12-14H,8-11H2,1-2H3,(H,25,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.2	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...				US Patent US9169260 (2015) BindingDB Entry DOI: 10.7270/Q26H4G6N
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM188932 (US9169260, 198) Show SMILES CN1CCN(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1 Show InChI InChI=1S/C21H23N9O/c1-15-4-5-17(23-13-15)30-18(12-19(26-30)28-10-8-27(2)9-11-28)25-21(31)16-14-24-29-7-3-6-22-20(16)29/h3-7,12-14H,8-11H2,1-2H3,(H,25,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of IRAK4 in human THP1-XBlue cells assessed as suppression of TLR4 agonist LPS-induced activation of NF-kappaB preincubated for 1 hr follo...				ACS Med Chem Lett 6: 677-82 (2015) Article DOI: 10.1021/acsmedchemlett.5b00106 BindingDB Entry DOI: 10.7270/Q2G73GGK
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM188932 (US9169260, 198) Show SMILES CN1CCN(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1 Show InChI InChI=1S/C21H23N9O/c1-15-4-5-17(23-13-15)30-18(12-19(26-30)28-10-8-27(2)9-11-28)25-21(31)16-14-24-29-7-3-6-22-20(16)29/h3-7,12-14H,8-11H2,1-2H3,(H,25,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal GST-tagged full length human IRAK4 expressed in baculovirus-infected insect Sf9 cells using 5FAM-RKRQGSVRRRVH-CO...				ACS Med Chem Lett 6: 677-82 (2015) Article DOI: 10.1021/acsmedchemlett.5b00106 BindingDB Entry DOI: 10.7270/Q2G73GGK
					More data for this Ligand-Target Pair