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BDBM188992 US9169260, 258

SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CC(C1)C#N

InChI Key: InChIKey=RZYHEUVLFOMLOZ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188992   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188992
PNG
(US9169260, 258)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCN(CC1)C1CC(C1)C#N |(8.22,1.68,;6.73,1.29,;6.33,-.2,;4.85,-.6,;3.76,.49,;4.16,1.98,;5.64,2.37,;2.27,.09,;1.79,-1.37,;.25,-1.37,;-.22,.09,;1.02,1,;1.02,2.54,;-.31,3.31,;-1.64,2.54,;-.31,4.85,;.94,5.75,;.46,7.22,;-1.08,7.22,;-2.11,8.36,;-3.62,8.04,;-4.09,6.57,;-3.06,5.43,;-1.56,5.75,;-.84,-2.46,;-2.32,-2.07,;-3.41,-3.15,;-3.01,-4.64,;-1.53,-5.04,;-.44,-3.95,;-4.1,-5.73,;-5.64,-5.73,;-5.64,-7.27,;-4.1,-7.27,;-6.73,-8.36,;-8.22,-7.96,)|
Show InChI InChI=1S/C27H28N8O/c1-18-3-5-21(6-4-18)35-25(31-27(36)23-17-30-34-10-2-9-29-26(23)34)15-24(32-35)20-7-11-33(12-8-20)22-13-19(14-22)16-28/h2-6,9-10,15,17,19-20,22H,7-8,11-14H2,1H3,(H,31,36)
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Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair