BDBM189007 US9169260, 273

SMILES: C[C@@H]1CCC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1

InChI Key: InChIKey=AKDGYVDSQQZQCK-ITUIMRKVSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189007   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM189007 (US9169260, 273) Show SMILES C[C@@H]1CCC(C1)N1CCC(CC1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(C)cn1 |r| Show InChI InChI=1S/C27H32N8O/c1-18-4-6-21(14-18)33-12-8-20(9-13-33)23-15-25(35(32-23)24-7-5-19(2)16-29-24)31-27(36)22-17-30-34-11-3-10-28-26(22)34/h3,5,7,10-11,15-18,20-21H,4,6,8-9,12-14H2,1-2H3,(H,31,36)/t18-,21?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.2	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...				US Patent US9169260 (2015) BindingDB Entry DOI: 10.7270/Q26H4G6N
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