BDBM189026 US9169260, 292

SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(Cc2ccc(F)cn2)C1

InChI Key: InChIKey=LLDQPDDLOPXAMP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189026   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM189026 (US9169260, 292) Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCCN(Cc2ccc(F)cn2)C1 Show InChI InChI=1S/C28H27FN8O/c1-19-5-9-23(10-6-19)37-26(33-28(38)24-16-32-36-13-3-11-30-27(24)36)14-25(34-37)20-4-2-12-35(17-20)18-22-8-7-21(29)15-31-22/h3,5-11,13-16,20H,2,4,12,17-18H2,1H3,(H,33,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<1.00E+3	n/a	n/a	n/a	n/a	7.2	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...				US Patent US9169260 (2015) BindingDB Entry DOI: 10.7270/Q26H4G6N
					More data for this Ligand-Target Pair