BDBM1891 1-[2-(2,6-difluorophenyl)ethyl]-3-(5-methylpyridin-2-yl)thiourea::N-(2-(2,6-Difluorophenyl)ethyl)-N -(2-(5-methylpyridyl))thiourea::PETT Analog 58

SMILES: Cc1ccc(NC(=S)NCCc2c(F)cccc2F)nc1

InChI Key: InChIKey=FIASQQMTLFRFPZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1891   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM1891 (1-[2-(2,6-difluorophenyl)ethyl]-3-(5-methylpyridin...) Show SMILES Cc1ccc(NC(=S)NCCc2c(F)cccc2F)nc1 Show InChI InChI=1S/C15H15F2N3S/c1-10-5-6-14(19-9-10)20-15(21)18-8-7-11-12(16)3-2-4-13(11)17/h2-6,9H,7-8H2,1H3,(H2,18,19,20,21)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	7.8	37
Lilly Research Laboratories					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 38: 4929-36 (1995) Article DOI: 10.1021/jm00025a010 BindingDB Entry DOI: 10.7270/Q2639MXG
					More data for this Ligand-Target Pair