BDBM189303 US9670194, Ex. 31 (S)-2-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyrimidin-4-yl)amino)propyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one

SMILES: CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(C)c2c(=O)n1-c1ccccc1C

InChI Key: InChIKey=FTAMGVHKRKINBA-KRWDZBQOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189303   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110δ/p85α (Homo sapiens (Human))	BDBM189303 (US9670194, Ex. 31 (S)-2-(1-((6-amino-5-(5-methyl-1...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(C)c2c(=O)n1-c1ccccc1C |r,wD:2.2,(4,.62,;2.67,1.39,;1.33,.62,;1.33,-.92,;2.67,-1.69,;4,-.92,;5.33,-1.69,;5.33,-3.23,;4,-4,;4,-5.54,;2.67,-3.23,;1.33,-4,;1.33,-5.54,;-.13,-6.01,;-1.04,-4.77,;-2.58,-4.77,;-.13,-3.52,;,1.39,;-1.33,.62,;-2.67,1.39,;-4,.62,;-5.33,1.39,;-5.33,2.93,;-4,3.7,;-4,5.24,;-2.67,2.93,;-1.33,3.7,;-1.33,5.24,;,2.93,;1.33,3.7,;2.67,2.93,;4,3.7,;4,5.24,;2.67,6.01,;1.33,5.24,;,6.01,)| Show InChI InChI=1S/C26H26N8O2/c1-5-17(30-23-21(22(27)28-13-29-23)25-33-32-16(4)36-25)24-31-18-11-8-10-15(3)20(18)26(35)34(24)19-12-7-6-9-14(19)2/h6-13,17H,5H2,1-4H3,(H3,27,28,29,30)/t17-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair