BDBM189305 US9670194, Ex. 33 (S)-2-(1-((6-amino-5-(5-methyl-1,2,4-oxadiazol-3-yl)pyrimidin-4-yl)amino)-ethyl)-5-chloro-3-cyclopropylquinazolin-4(3H)-one

SMILES: C[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1nc2cccc(Cl)c2c(=O)n1C1CC1

InChI Key: InChIKey=HWZUVJKRMZEIDE-VIFPVBQESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189305   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110δ/p85α (Homo sapiens (Human))	BDBM189305 (US9670194, Ex. 33 (S)-2-(1-((6-amino-5-(5-methyl-1...) Show SMILES C[C@H](Nc1ncnc(N)c1-c1noc(C)n1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C20H19ClN8O2/c1-9(25-17-15(16(22)23-8-24-17)18-26-10(2)31-28-18)19-27-13-5-3-4-12(21)14(13)20(30)29(19)11-6-7-11/h3-5,8-9,11H,6-7H2,1-2H3,(H3,22,23,24,25)/t9-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
					More data for this Ligand-Target Pair