BDBM189380 5-methyl-4-(2-thiazolylazo)resorcinol::PTK66

SMILES: Cc1cc(O)cc(O)c1\N=N\c1nccs1

InChI Key: InChIKey=LABKTXRFMJIJAU-OUKQBFOZSA-N

Data: 2 Kd  2 ITC

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 189380   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase B (Homo sapiens (Human))	BDBM189380 (5-methyl-4-(2-thiazolylazo)resorcinol | PTK66) Show SMILES Cc1cc(O)cc(O)c1\N=N\c1nccs1 Show InChI InChI=1S/C10H9N3O2S/c1-6-4-7(14)5-8(15)9(6)12-13-10-11-2-3-16-10/h2-5,14-15H,1H3/b13-12+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	500	n/a	n/a	n/a	8.0	25
Jawaharlal Nehru Centre for Advanced Scientific Research					Assay Description Calorimetric titrations were performed in a Microcal iTC 200 microcalorimeter. Freshly purified 5 µM protein (Aurora A/B kinases) was titrated agains...				Chem Biol Drug Des 87: 958-67 (2016) Article DOI: 10.1111/cbdd.12728 BindingDB Entry DOI: 10.7270/Q2D21WDJ
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM189380 (5-methyl-4-(2-thiazolylazo)resorcinol | PTK66) Show SMILES Cc1cc(O)cc(O)c1\N=N\c1nccs1 Show InChI InChI=1S/C10H9N3O2S/c1-6-4-7(14)5-8(15)9(6)12-13-10-11-2-3-16-10/h2-5,14-15H,1H3/b13-12+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.75E+3	n/a	n/a	n/a	8.0	25
Jawaharlal Nehru Centre for Advanced Scientific Research					Assay Description Calorimetric titrations were performed in a Microcal iTC 200 microcalorimeter. Freshly purified 5 µM protein (Aurora A/B kinases) was titrated agains...				Chem Biol Drug Des 87: 958-67 (2016) Article DOI: 10.1111/cbdd.12728 BindingDB Entry DOI: 10.7270/Q2D21WDJ
					More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 2 hits for monomerid = 189380

Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kcal/mole	-TΔS° kcal/mole	ΔH° kcal/mole	log K	pH	Temp °C
Serine/threonine-protein kinase Aurora-B (Homo sapiens (Human))	BDBM189380 (5-methyl-4-(2-thiazolylazo)resorcinol | PTK66)	GoogleScholar PDB	PC cid PC sid		-7.88	6.02	-13.9	5.78	8	25
Jawaharlal Nehru Centre for Advanced Scientific Research					Chem Biol Drug Des 87: 958-67 (2016)
Serine/threonine-protein kinase Aurora-B (Homo sapiens (Human))	BDBM189380 (5-methyl-4-(2-thiazolylazo)resorcinol | PTK66)	GoogleScholar PDB	PC cid PC sid		-9.31	5.45	-25.8	6.83	8	25
Jawaharlal Nehru Centre for Advanced Scientific Research					Chem Biol Drug Des 87: 958-67 (2016)