BDBM189588 US10213433, Compound 150::US9174982, 150

SMILES: CC1(C)CCCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C1c1ccc(Cl)cc1

InChI Key: InChIKey=FGLBNVNJFBVRSE-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 189588   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189588 (US10213433, Compound 150 | US9174982, 150) Show SMILES CC1(C)CCCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C1c1ccc(Cl)cc1 |c:58| Show InChI InChI=1S/C45H50ClN7O7S/c1-45(2)16-3-4-33(42(45)31-5-7-34(46)8-6-31)29-51-18-20-52(21-19-51)35-9-11-38(41(25-35)60-36-24-32-13-17-47-43(32)49-28-36)44(54)50-61(57,58)37-10-12-39(40(26-37)53(55)56)48-27-30-14-22-59-23-15-30/h5-13,17,24-26,28,30,48H,3-4,14-16,18-23,27,29H2,1-2H3,(H,47,49)(H,50,54)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189588 (US10213433, Compound 150 | US9174982, 150) Show SMILES CC1(C)CCCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C1c1ccc(Cl)cc1 |c:58| Show InChI InChI=1S/C45H50ClN7O7S/c1-45(2)16-3-4-33(42(45)31-5-7-34(46)8-6-31)29-51-18-20-52(21-19-51)35-9-11-38(41(25-35)60-36-24-32-13-17-47-43(32)49-28-36)44(54)50-61(57,58)37-10-12-39(40(26-37)53(55)56)48-27-30-14-22-59-23-15-30/h5-13,17,24-26,28,30,48H,3-4,14-16,18-23,27,29H2,1-2H3,(H,47,49)(H,50,54)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9174982 (2015) BindingDB Entry DOI: 10.7270/Q2RB73D5
					More data for this Ligand-Target Pair