null

SMILES: [O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CCC3(CCN(CC3)C(CF)CF)C2)c2ccc(Cl)cc2)CC1

InChI Key: InChIKey=FRLNKPKUSFDSGE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 189695   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189695 (US10213433, Compound 265 | US11369599, Compound 26...) Show SMILES [O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CCC3(CCN(CC3)C(CF)CF)C2)c2ccc(Cl)cc2)CC1 |t:49| Show InChI InChI=1S/C50H57ClF2N8O7S/c51-38-3-1-35(2-4-38)43-9-13-50(14-17-59(18-15-50)40(29-52)30-53)28-37(43)33-58-19-21-60(22-20-58)39-5-7-44(47(26-39)68-41-25-36-10-16-54-48(36)56-32-41)49(62)57-69(65,66)42-6-8-45(46(27-42)61(63)64)55-31-34-11-23-67-24-12-34/h1-8,10,16,25-27,32,34,40,55H,9,11-15,17-24,28-31,33H2,(H,54,56)(H,57,62)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9174982 (2015) BindingDB Entry DOI: 10.7270/Q2RB73D5
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189695 (US10213433, Compound 265 | US11369599, Compound 26...) Show SMILES [O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CCC3(CCN(CC3)C(CF)CF)C2)c2ccc(Cl)cc2)CC1 |t:49| Show InChI InChI=1S/C50H57ClF2N8O7S/c51-38-3-1-35(2-4-38)43-9-13-50(14-17-59(18-15-50)40(29-52)30-53)28-37(43)33-58-19-21-60(22-20-58)39-5-7-44(47(26-39)68-41-25-36-10-16-54-48(36)56-32-41)49(62)57-69(65,66)42-6-8-45(46(27-42)61(63)64)55-31-34-11-23-67-24-12-34/h1-8,10,16,25-27,32,34,40,55H,9,11-15,17-24,28-31,33H2,(H,54,56)(H,57,62)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The inhibition constant (Ki) for binding of representative compounds to Bcl-2 protein, as determined by a TR-FRET (Time-Resolved Fluorescence-Resonan...				Citation and Details BindingDB Entry DOI: 10.7270/Q21V5J59
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189695 (US10213433, Compound 265 | US11369599, Compound 26...) Show SMILES [O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CCC3(CCN(CC3)C(CF)CF)C2)c2ccc(Cl)cc2)CC1 |t:49| Show InChI InChI=1S/C50H57ClF2N8O7S/c51-38-3-1-35(2-4-38)43-9-13-50(14-17-59(18-15-50)40(29-52)30-53)28-37(43)33-58-19-21-60(22-20-58)39-5-7-44(47(26-39)68-41-25-36-10-16-54-48(36)56-32-41)49(62)57-69(65,66)42-6-8-45(46(27-42)61(63)64)55-31-34-11-23-67-24-12-34/h1-8,10,16,25-27,32,34,40,55H,9,11-15,17-24,28-31,33H2,(H,54,56)(H,57,62)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair