BDBM189805 US9174993, 42::US9221828, 42
SMILES: Fc1cc(F)c(cc1Cl)S(=O)(=O)Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2cc(Cl)c(F)cc2F)cc1
InChI Key: InChIKey=GFFUAEKPDJYQRA-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human)) | BDBM189805 (US9174993, 42 | US9221828, 42) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 413 | n/a | n/a | n/a | n/a | 7.4 | 24 |
SANOFI US Patent | Assay Description The enzyme reaction was carried out in a buffer containing 25 mM Tris-HCl (pH 7.4), 5 mM MgCl2, 2 mM MnCl2, 2 mM DTT, and 0.03% bovine serum albumi... | US Patent US9221828 (2015) BindingDB Entry DOI: 10.7270/Q2GX49DW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human)) | BDBM189805 (US9174993, 42 | US9221828, 42) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 413 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI US Patent | Assay Description The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t... | US Patent US9174993 (2015) BindingDB Entry DOI: 10.7270/Q2MK6BPF | |||||||||||
More data for this Ligand-Target Pair |