BDBM189832 US9670194, Ex. 52 (S)-2-(1-((6-amino-5-(4-methyloxazol-2-yl)pyrimidin-4-yl)amino)propyl)-5-chloro-3-cyclopropylquinazolin-4(3H)-one

SMILES: CC[C@H](Nc1ncnc(N)c1-c1nc(C)co1)c1nc2cccc(Cl)c2c(=O)n1C1CC1

InChI Key: InChIKey=MVFPDBPZLUHHTE-AWEZNQCLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189832   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110δ/p85α (Homo sapiens (Human))	BDBM189832 (US9670194, Ex. 52 (S)-2-(1-((6-amino-5-(4-methylox...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)co1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C22H22ClN7O2/c1-3-14(28-19-17(18(24)25-10-26-19)21-27-11(2)9-32-21)20-29-15-6-4-5-13(23)16(15)22(31)30(20)12-7-8-12/h4-6,9-10,12,14H,3,7-8H2,1-2H3,(H3,24,25,26,28)/t14-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
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