BDBM189837 US9670194, Ex. 56 (S)-2-(1-((6-amino-5-(3-ethyl-1,2,4-oxadiazol-5-yl)pyrimidin-4-yl)amino)-propyl)-5-chloro-3-cyclopropylquinazolin-4(3H)-one

SMILES: CC[C@H](Nc1ncnc(N)c1-c1nc(CC)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1

InChI Key: InChIKey=SBUOLWIFHXGUAY-ZDUSSCGKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189837   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
p110δ/p85α (Homo sapiens (Human))	BDBM189837 (US9670194, Ex. 56 (S)-2-(1-((6-amino-5-(3-ethyl-1,...) Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(CC)no1)c1nc2cccc(Cl)c2c(=O)n1C1CC1 |r| Show InChI InChI=1S/C22H23ClN8O2/c1-3-13(27-19-17(18(24)25-10-26-19)21-29-15(4-2)30-33-21)20-28-14-7-5-6-12(23)16(14)22(32)31(20)11-8-9-11/h5-7,10-11,13H,3-4,8-9H2,1-2H3,(H3,24,25,26,27)/t13-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	25
CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...				US Patent US9670194 (2017) BindingDB Entry DOI: 10.7270/Q2NS0S1D
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