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SMILES: CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1C[C@@H]1F

InChI Key: InChIKey=MARDRRMXZDSLJS-SGMGOOAPSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189843   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform


(Homo sapiens (Human))		BDBM189843
PNG
(US9670194, Ex. 62 2-((S)-1-((6-amino-5-(3-methyl-1...)
Show SMILES CC[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1nc2cccc(Cl)c2c(=O)n1[C@@H]1C[C@@H]1F |r|
Show InChI InChI=1S/C21H20ClFN8O2/c1-3-12(28-18-16(17(24)25-8-26-18)20-27-9(2)30-33-20)19-29-13-6-4-5-10(22)15(13)21(32)31(19)14-7-11(14)23/h4-6,8,11-12,14H,3,7H2,1-2H3,(H3,24,25,26,28)/t11-,12-,14+/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 37n/an/an/an/an/a25



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...

US Patent US9670194 (2017)


BindingDB Entry DOI: 10.7270/Q2NS0S1D
More data for this
Ligand-Target Pair