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SMILES: Cc1nc(NC(=O)C2CCC2)sc1S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1

InChI Key: InChIKey=HSXBCSCPAUQQEM-HNGVJOSZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189947   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189947
PNG
(US9175003, 55)
Show SMILES Cc1nc(NC(=O)C2CCC2)sc1S(=O)(=O)N1Cc2cc3OC(COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C50H43Cl2N5O9S2/c1-28-49(67-50(54-28)56-46(58)35-3-2-4-35)68(62,63)57-25-37-23-44-43(65-27-45(66-44)34-14-16-38(17-15-34)64-26-31-9-18-39(51)40(52)19-31)22-36(37)21-42(57)47(59)55-41(48(60)61)20-29-5-10-32(11-6-29)33-12-7-30(24-53)8-13-33/h5-19,22-23,35,41-42,45H,2-4,20-21,25-27H2,1H3,(H,55,59)(H,60,61)(H,54,56,58)/t41-,42-,45?/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
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UniChem

Similars
US Patent
n/an/an/an/a 360n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair