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SMILES: CCNc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3O[C@@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1

InChI Key: InChIKey=TXRCDBCTPYYQIT-RNMNAOLMSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 189950   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM189950
PNG
(US9175003, 62)
Show SMILES CCNc1nc(C)c(s1)S(=O)(=O)N1Cc2cc3O[C@@H](COc3cc2C[C@H]1C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(cc1)C#N)C(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r|
Show InChI InChI=1S/C47H41Cl2N5O8S2/c1-3-51-47-52-27(2)46(63-47)64(58,59)54-24-35-22-42-41(61-26-43(62-42)33-13-15-36(16-14-33)60-25-30-8-17-37(48)38(49)18-30)21-34(35)20-40(54)44(55)53-39(45(56)57)19-28-4-9-31(10-5-28)32-11-6-29(23-50)7-12-32/h4-18,21-22,39-40,43H,3,19-20,24-26H2,1-2H3,(H,51,52)(H,53,55)(H,56,57)/t39-,40-,43-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 328n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair