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SMILES: Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)[C@H]2CCCN2C(=O)OC(C)(C)C)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1

InChI Key: InChIKey=OTKURAIBHFDTRP-JOMKNHSZSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 190082   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM190082
PNG
(US9175003, 279)
Show SMILES Cc1nccc(c1C)-c1ccc(C[C@H](NC(=O)[C@@H]2Cc3cc4OC[C@@H](Oc4cc3CN2C(=O)[C@H]2CCCN2C(=O)OC(C)(C)C)c2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C51H52Cl2N4O9/c1-29-30(2)54-19-18-38(29)33-11-8-31(9-12-33)22-41(49(60)61)55-47(58)43-23-35-24-44-45(25-36(35)26-57(43)48(59)42-7-6-20-56(42)50(62)66-51(3,4)5)65-46(28-64-44)34-13-15-37(16-14-34)63-27-32-10-17-39(52)40(53)21-32/h8-19,21,24-25,41-43,46H,6-7,20,22-23,26-28H2,1-5H3,(H,55,58)(H,60,61)/t41-,42+,43-,46+/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/an/an/a 15n/an/an/an/a



vTv Therapeutics LLC

US Patent


Assay Description
The efficacy of GLP-1 receptor agonists was studied in a cAMP functional assay using HEK-293 Cells expressing the cloned human GLP-1 receptor. GLP-1-...

US Patent US9175003 (2015)


BindingDB Entry DOI: 10.7270/Q27943FG
More data for this
Ligand-Target Pair