BDBM190183 EPZ006438::US9175331, 9
SMILES: CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)nc2=O)c1C)-c1ccc(CN2CCOCC2)cc1
InChI Key: InChIKey=HFPUPAPOXUOVAC-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat... | US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat... | US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (A677G) (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat... | US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (A687V) (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat... | US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | n/a | n/a | 5.03 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | n/a | n/a | 11.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | n/a | n/a | 655 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | n/a | n/a | 7.07 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM190183 (EPZ006438 | US11052093, Compound 139 | US9175331, ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair |