null

SMILES: CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Cl)cc(N(CC)C2CCN(C)CC2)c1C

InChI Key: InChIKey=COKYRVNIWHYRPM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190224   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM190224 (EPZ009162 | US9175331, 62) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Cl)cc(N(CC)C2CCN(C)CC2)c1C Show InChI InChI=1S/C26H37ClN4O2/c1-6-8-19-13-17(3)29-26(33)23(19)16-28-25(32)22-14-20(27)15-24(18(22)4)31(7-2)21-9-11-30(5)12-10-21/h13-15,21H,6-12,16H2,1-5H3,(H,28,32)(H,29,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	65.7	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A687V] (Homo sapiens (Human))	BDBM190224 (EPZ009162 | US9175331, 62) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Cl)cc(N(CC)C2CCN(C)CC2)c1C Show InChI InChI=1S/C26H37ClN4O2/c1-6-8-19-13-17(3)29-26(33)23(19)16-28-25(32)22-14-20(27)15-24(18(22)4)31(7-2)21-9-11-30(5)12-10-21/h13-15,21H,6-12,16H2,1-5H3,(H,28,32)(H,29,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	17.8	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [A677G] (Homo sapiens (Human))	BDBM190224 (EPZ009162 | US9175331, 62) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Cl)cc(N(CC)C2CCN(C)CC2)c1C Show InChI InChI=1S/C26H37ClN4O2/c1-6-8-19-13-17(3)29-26(33)23(19)16-28-25(32)22-14-20(27)15-24(18(22)4)31(7-2)21-9-11-30(5)12-10-21/h13-15,21H,6-12,16H2,1-5H3,(H,28,32)(H,29,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14.6	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human))	BDBM190224 (EPZ009162 | US9175331, 62) Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Cl)cc(N(CC)C2CCN(C)CC2)c1C Show InChI InChI=1S/C26H37ClN4O2/c1-6-8-19-13-17(3)29-26(33)23(19)16-28-25(32)22-14-20(27)15-24(18(22)4)31(7-2)21-9-11-30(5)12-10-21/h13-15,21H,6-12,16H2,1-5H3,(H,28,32)(H,29,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	35.1	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...				US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP
					More data for this Ligand-Target Pair