BDBM190301 US10227346, Example 63::US10426135, Example 63::US9670201, 63 (R)-3-chloro-N-(3-(1-(cyclopentane-carbonyl)-2,2-dimethylpiperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-methoxybenzamide::US9920054, Example 63

SMILES: COc1cc(Cl)cc(c1)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c2c1C

InChI Key: InChIKey=HWFUUWBYBMAHRO-HXUWFJFHSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190301   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM190301 (US10227346, Example 63 | US10426135, Example 63 | ...) Show SMILES COc1cc(Cl)cc(c1)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c2c1C |r| Show InChI InChI=1S/C30H37ClN4O3/c1-18-25(33-28(36)21-12-22(31)14-23(13-21)38-5)16-32-27-26(18)24(17-34(27)4)20-10-11-35(30(2,3)15-20)29(37)19-8-6-7-9-19/h12-14,16-17,19-20H,6-11,15H2,1-5H3,(H,33,36)/t20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	25
Pfizer Inc. US Patent					Assay Description Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...				US Patent US9670201 (2017) BindingDB Entry DOI: 10.7270/Q28G8HWT
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM190301 (US10227346, Example 63 | US10426135, Example 63 | ...) Show SMILES COc1cc(Cl)cc(c1)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c2c1C |r| Show InChI InChI=1S/C30H37ClN4O3/c1-18-25(33-28(36)21-12-22(31)14-23(13-21)38-5)16-32-27-26(18)24(17-34(27)4)20-10-11-35(30(2,3)15-20)29(37)19-8-6-7-9-19/h12-14,16-17,19-20H,6-11,15H2,1-5H3,(H,33,36)/t20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...				US Patent US10426135 (2019) BindingDB Entry DOI: 10.7270/Q23N25QB
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM190301 (US10227346, Example 63 | US10426135, Example 63 | ...) Show SMILES COc1cc(Cl)cc(c1)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c2c1C |r| Show InChI InChI=1S/C30H37ClN4O3/c1-18-25(33-28(36)21-12-22(31)14-23(13-21)38-5)16-32-27-26(18)24(17-34(27)4)20-10-11-35(30(2,3)15-20)29(37)19-8-6-7-9-19/h12-14,16-17,19-20H,6-11,15H2,1-5H3,(H,33,36)/t20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University									J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q2GH9M91
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM190301 (US10227346, Example 63 | US10426135, Example 63 | ...) Show SMILES COc1cc(Cl)cc(c1)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c2c1C |r| Show InChI InChI=1S/C30H37ClN4O3/c1-18-25(33-28(36)21-12-22(31)14-23(13-21)38-5)16-32-27-26(18)24(17-34(27)4)20-10-11-35(30(2,3)15-20)29(37)19-8-6-7-9-19/h12-14,16-17,19-20H,6-11,15H2,1-5H3,(H,33,36)/t20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2SF2ZGV
					More data for this Ligand-Target Pair