BDBM190303 US10227346, Example 64::US10426135, Example 64::US9670201, 64 (R)-3-cyano-N-(3-(1-(cyclopentanecarbonyl)-2,2-dimethylpiperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-hydroxybenzamide::US9920054, Example 64

SMILES: Cc1c(NC(=O)c2cc(O)cc(c2)C#N)cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c12

InChI Key: InChIKey=MZJJSBJERQYTGJ-OAQYLSRUSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190303   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM190303 (US10227346, Example 64 | US10426135, Example 64 | ...) Show SMILES Cc1c(NC(=O)c2cc(O)cc(c2)C#N)cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c12 |r| Show InChI InChI=1S/C30H35N5O3/c1-18-25(33-28(37)22-11-19(15-31)12-23(36)13-22)16-32-27-26(18)24(17-34(27)4)21-9-10-35(30(2,3)14-21)29(38)20-7-5-6-8-20/h11-13,16-17,20-21,36H,5-10,14H2,1-4H3,(H,33,37)/t21-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	7.5	25
Pfizer Inc. US Patent					Assay Description Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...				US Patent US9670201 (2017) BindingDB Entry DOI: 10.7270/Q28G8HWT
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM190303 (US10227346, Example 64 | US10426135, Example 64 | ...) Show SMILES Cc1c(NC(=O)c2cc(O)cc(c2)C#N)cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c12 |r| Show InChI InChI=1S/C30H35N5O3/c1-18-25(33-28(37)22-11-19(15-31)12-23(36)13-22)16-32-27-26(18)24(17-34(27)4)21-9-10-35(30(2,3)14-21)29(38)20-7-5-6-8-20/h11-13,16-17,20-21,36H,5-10,14H2,1-4H3,(H,33,37)/t21-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41.8	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...				US Patent US10426135 (2019) BindingDB Entry DOI: 10.7270/Q23N25QB
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM190303 (US10227346, Example 64 | US10426135, Example 64 | ...) Show SMILES Cc1c(NC(=O)c2cc(O)cc(c2)C#N)cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c12 |r| Show InChI InChI=1S/C30H35N5O3/c1-18-25(33-28(37)22-11-19(15-31)12-23(36)13-22)16-32-27-26(18)24(17-34(27)4)21-9-10-35(30(2,3)14-21)29(38)20-7-5-6-8-20/h11-13,16-17,20-21,36H,5-10,14H2,1-4H3,(H,33,37)/t21-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41.8	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University									J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q2GH9M91
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM190303 (US10227346, Example 64 | US10426135, Example 64 | ...) Show SMILES Cc1c(NC(=O)c2cc(O)cc(c2)C#N)cnc2n(C)cc([C@@H]3CCN(C(=O)C4CCCC4)C(C)(C)C3)c12 |r| Show InChI InChI=1S/C30H35N5O3/c1-18-25(33-28(37)22-11-19(15-31)12-23(36)13-22)16-32-27-26(18)24(17-34(27)4)21-9-10-35(30(2,3)14-21)29(38)20-7-5-6-8-20/h11-13,16-17,20-21,36H,5-10,14H2,1-4H3,(H,33,37)/t21-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41.8	n/a	n/a	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2SF2ZGV
					More data for this Ligand-Target Pair