BDBM190311 US10227346, Example 69::US10426135, Example 69::US9670201, 69 3-cyano-N-(3-((R)-2,2-dimethyl-1-((R)-2,3,3-trimethylbutanoyl)piperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-4-methoxybenzamide::US9920054, Example 69

SMILES: COc1ccc(cc1C#N)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)[C@H](C)C(C)(C)C)C(C)(C)C3)c2c1C

InChI Key: InChIKey=LLSZHCLFSVLMFU-RBBKRZOGSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190311   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM190311 (US10227346, Example 69 | US10426135, Example 69 | ...) Show SMILES COc1ccc(cc1C#N)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)[C@H](C)C(C)(C)C)C(C)(C)C3)c2c1C |r| Show InChI InChI=1S/C32H41N5O3/c1-19-25(35-29(38)21-10-11-26(40-9)23(14-21)16-33)17-34-28-27(19)24(18-36(28)8)22-12-13-37(32(6,7)15-22)30(39)20(2)31(3,4)5/h10-11,14,17-18,20,22H,12-13,15H2,1-9H3,(H,35,38)/t20-,22+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	25
Pfizer Inc. US Patent					Assay Description Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...				US Patent US9670201 (2017) BindingDB Entry DOI: 10.7270/Q28G8HWT
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM190311 (US10227346, Example 69 | US10426135, Example 69 | ...) Show SMILES COc1ccc(cc1C#N)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)[C@H](C)C(C)(C)C)C(C)(C)C3)c2c1C |r| Show InChI InChI=1S/C32H41N5O3/c1-19-25(35-29(38)21-10-11-26(40-9)23(14-21)16-33)17-34-28-27(19)24(18-36(28)8)22-12-13-37(32(6,7)15-22)30(39)20(2)31(3,4)5/h10-11,14,17-18,20,22H,12-13,15H2,1-9H3,(H,35,38)/t20-,22+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...				US Patent US10426135 (2019) BindingDB Entry DOI: 10.7270/Q23N25QB
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM190311 (US10227346, Example 69 | US10426135, Example 69 | ...) Show SMILES COc1ccc(cc1C#N)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)[C@H](C)C(C)(C)C)C(C)(C)C3)c2c1C |r| Show InChI InChI=1S/C32H41N5O3/c1-19-25(35-29(38)21-10-11-26(40-9)23(14-21)16-33)17-34-28-27(19)24(18-36(28)8)22-12-13-37(32(6,7)15-22)30(39)20(2)31(3,4)5/h10-11,14,17-18,20,22H,12-13,15H2,1-9H3,(H,35,38)/t20-,22+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University									J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q2GH9M91
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human))	BDBM190311 (US10227346, Example 69 | US10426135, Example 69 | ...) Show SMILES COc1ccc(cc1C#N)C(=O)Nc1cnc2n(C)cc([C@@H]3CCN(C(=O)[C@H](C)C(C)(C)C)C(C)(C)C3)c2c1C |r| Show InChI InChI=1S/C32H41N5O3/c1-19-25(35-29(38)21-10-11-26(40-9)23(14-21)16-33)17-34-28-27(19)24(18-36(28)8)22-12-13-37(32(6,7)15-22)30(39)20(2)31(3,4)5/h10-11,14,17-18,20,22H,12-13,15H2,1-9H3,(H,35,38)/t20-,22+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
Universita di Napoli					Assay Description The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...				J Med Chem 51: 1764-70 (2008) BindingDB Entry DOI: 10.7270/Q2SF2ZGV
					More data for this Ligand-Target Pair