BDBM191146 US9181266, 8

SMILES: COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCCCc3c(=O)[nH]2)CC1

InChI Key: InChIKey=JAQISDRQXHHOJS-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 191146   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM191146 (US9181266, 8) Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCCCc3c(=O)[nH]2)CC1 Show InChI InChI=1S/C28H36N4O4/c1-36-22-10-8-20(9-11-22)27(34)21-12-14-31(15-13-21)18-26(33)32(16-19-6-7-19)17-25-29-24-5-3-2-4-23(24)28(35)30-25/h8-11,19,21H,2-7,12-18H2,1H3,(H,29,30,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...				US Patent US9181266 (2015) BindingDB Entry DOI: 10.7270/Q20P0XTF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM191146 (US9181266, 8) Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCCCc3c(=O)[nH]2)CC1 Show InChI InChI=1S/C28H36N4O4/c1-36-22-10-8-20(9-11-22)27(34)21-12-14-31(15-13-21)18-26(33)32(16-19-6-7-19)17-25-29-24-5-3-2-4-23(24)28(35)30-25/h8-11,19,21H,2-7,12-18H2,1H3,(H,29,30,35)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.14E+3	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...				US Patent US9181266 (2015) BindingDB Entry DOI: 10.7270/Q20P0XTF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM191146 (US9181266, 8) Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCCCc3c(=O)[nH]2)CC1 Show InChI InChI=1S/C28H36N4O4/c1-36-22-10-8-20(9-11-22)27(34)21-12-14-31(15-13-21)18-26(33)32(16-19-6-7-19)17-25-29-24-5-3-2-4-23(24)28(35)30-25/h8-11,19,21H,2-7,12-18H2,1H3,(H,29,30,35)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.64E+4	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...				US Patent US9181266 (2015) BindingDB Entry DOI: 10.7270/Q20P0XTF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM191146 (US9181266, 8) Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc3CCCCc3c(=O)[nH]2)CC1 Show InChI InChI=1S/C28H36N4O4/c1-36-22-10-8-20(9-11-22)27(34)21-12-14-31(15-13-21)18-26(33)32(16-19-6-7-19)17-25-29-24-5-3-2-4-23(24)28(35)30-25/h8-11,19,21H,2-7,12-18H2,1H3,(H,29,30,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...				US Patent US9181266 (2015) BindingDB Entry DOI: 10.7270/Q20P0XTF
					More data for this Ligand-Target Pair