BDBM191177 US9181266, 46

SMILES: Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2ccc(s2)C#N)Cc2nc3CCOCc3c(=O)[nH]2)CC1

InChI Key: InChIKey=KFHSJMVNDVHQGS-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 191177   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM191177 (US9181266, 46) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2ccc(s2)C#N)Cc2nc3CCOCc3c(=O)[nH]2)CC1 Show InChI InChI=1S/C28H28FN5O4S/c29-20-3-1-18(2-4-20)27(36)19-7-10-33(11-8-19)16-26(35)34(14-22-6-5-21(13-30)39-22)15-25-31-24-9-12-38-17-23(24)28(37)32-25/h1-6,19H,7-12,14-17H2,(H,31,32,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...				US Patent US9181266 (2015) BindingDB Entry DOI: 10.7270/Q20P0XTF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM191177 (US9181266, 46) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2ccc(s2)C#N)Cc2nc3CCOCc3c(=O)[nH]2)CC1 Show InChI InChI=1S/C28H28FN5O4S/c29-20-3-1-18(2-4-20)27(36)19-7-10-33(11-8-19)16-26(35)34(14-22-6-5-21(13-30)39-22)15-25-31-24-9-12-38-17-23(24)28(37)32-25/h1-6,19H,7-12,14-17H2,(H,31,32,37)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...				US Patent US9181266 (2015) BindingDB Entry DOI: 10.7270/Q20P0XTF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM191177 (US9181266, 46) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2ccc(s2)C#N)Cc2nc3CCOCc3c(=O)[nH]2)CC1 Show InChI InChI=1S/C28H28FN5O4S/c29-20-3-1-18(2-4-20)27(36)19-7-10-33(11-8-19)16-26(35)34(14-22-6-5-21(13-30)39-22)15-25-31-24-9-12-38-17-23(24)28(37)32-25/h1-6,19H,7-12,14-17H2,(H,31,32,37)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...				US Patent US9181266 (2015) BindingDB Entry DOI: 10.7270/Q20P0XTF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM191177 (US9181266, 46) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC(=O)N(Cc2ccc(s2)C#N)Cc2nc3CCOCc3c(=O)[nH]2)CC1 Show InChI InChI=1S/C28H28FN5O4S/c29-20-3-1-18(2-4-20)27(36)19-7-10-33(11-8-19)16-26(35)34(14-22-6-5-21(13-30)39-22)15-25-31-24-9-12-38-17-23(24)28(37)32-25/h1-6,19H,7-12,14-17H2,(H,31,32,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...				US Patent US9181266 (2015) BindingDB Entry DOI: 10.7270/Q20P0XTF
					More data for this Ligand-Target Pair