BDBM19220 (R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4aH,5H,6H,7H,8H-cyclohexa[f]indazol-5-yl](1-benzothiophen-2-yl)methanol::CHEMBL195972::benzo[f]indazole, 13

SMILES: [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1cc2ccccc2s1

InChI Key: InChIKey=JDLFGDLBJAKKML-XCRWMPKNSA-N

Data: 2 IC50  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 19220   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM19220 ((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...) Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1cc2ccccc2s1 |r,t:5| Show InChI InChI=1S/C27H25FN2OS/c1-27-15-18-16-29-30(21-11-9-20(28)10-12-21)23(18)14-19(27)6-4-7-22(27)26(31)25-13-17-5-2-3-8-24(17)32-25/h2-3,5,8-14,16,22,26,31H,4,6-7,15H2,1H3/t22-,26-,27+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29.1	n/a	19	n/a	n/a	7.5	4
Merck Research Laboratories					Assay Description The IC50s were determined by incubating the receptors with radiolabeled dexamethasone in the presence of full log scale concentrations (10-11 M to 10...				Bioorg Med Chem Lett 17: 3354-61 (2007) Article DOI: 10.1016/j.bmcl.2007.03.103 BindingDB Entry DOI: 10.7270/Q2542KVJ
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM19220 ((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...) Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1cc2ccccc2s1 |r,t:5| Show InChI InChI=1S/C27H25FN2OS/c1-27-15-18-16-29-30(21-11-9-20(28)10-12-21)23(18)14-19(27)6-4-7-22(27)26(31)25-13-17-5-2-3-8-24(17)32-25/h2-3,5,8-14,16,22,26,31H,4,6-7,15H2,1H3/t22-,26-,27+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	29.1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human glucocorticoid receptor alpha by displacement of [3H]-dexamethasone				Bioorg Med Chem Lett 15: 2163-7 (2005) Article DOI: 10.1016/j.bmcl.2005.02.009 BindingDB Entry DOI: 10.7270/Q2WM1CXX
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM19220 ((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...) Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1cc2ccccc2s1 |r,t:5| Show InChI InChI=1S/C27H25FN2OS/c1-27-15-18-16-29-30(21-11-9-20(28)10-12-21)23(18)14-19(27)6-4-7-22(27)26(31)25-13-17-5-2-3-8-24(17)32-25/h2-3,5,8-14,16,22,26,31H,4,6-7,15H2,1H3/t22-,26-,27+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description GR-mediated transrepression of IL-6 in human A549 lung carcinoma cells				Bioorg Med Chem Lett 15: 2163-7 (2005) Article DOI: 10.1016/j.bmcl.2005.02.009 BindingDB Entry DOI: 10.7270/Q2WM1CXX
					More data for this Ligand-Target Pair
Glucocorticoid (MOUSE)	BDBM19220 ((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...) Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1cc2ccccc2s1 |r,t:5| Show InChI InChI=1S/C27H25FN2OS/c1-27-15-18-16-29-30(21-11-9-20(28)10-12-21)23(18)14-19(27)6-4-7-22(27)26(31)25-13-17-5-2-3-8-24(17)32-25/h2-3,5,8-14,16,22,26,31H,4,6-7,15H2,1H3/t22-,26-,27+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.21E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse glutamine synthetase by GR-mediated transactivation in C2C12 cells				Bioorg Med Chem Lett 15: 2163-7 (2005) Article DOI: 10.1016/j.bmcl.2005.02.009 BindingDB Entry DOI: 10.7270/Q2WM1CXX
					More data for this Ligand-Target Pair
Glucocorticoid (MOUSE)	BDBM19220 ((R)-[(4aR,5S)-1-(4-fluorophenyl)-4a-methyl-1H,4H,4...) Show SMILES [H][C@@]1(CCCC2=Cc3c(C[C@]12C)cnn3-c1ccc(F)cc1)[C@@H](O)c1cc2ccccc2s1 |r,t:5| Show InChI InChI=1S/C27H25FN2OS/c1-27-15-18-16-29-30(21-11-9-20(28)10-12-21)23(18)14-19(27)6-4-7-22(27)26(31)25-13-17-5-2-3-8-24(17)32-25/h2-3,5,8-14,16,22,26,31H,4,6-7,15H2,1H3/t22-,26-,27+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description GR-mediated transrepression of IL-6 in peritoneal exudate cells harvested from C57BI/6 mice				Bioorg Med Chem Lett 15: 2163-7 (2005) Article DOI: 10.1016/j.bmcl.2005.02.009 BindingDB Entry DOI: 10.7270/Q2WM1CXX
					More data for this Ligand-Target Pair