BDBM19238 2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-methanesulfonamido-2-methylphenyl)amino}methyl)phenoxy]phenoxy}acetic acid::GR sulfonamide modulator, 15
SMILES: Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccc(Oc2ccc(Cl)c(OCC(O)=O)c2)cc1)Cc1ccc(F)cc1F
InChI Key: InChIKey=USLSTEHVCOVPEK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucocorticoid receptor (Homo sapiens (Human)) | BDBM19238![]() (2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60 | n/a | 500 | n/a | n/a | 8.0 | 4 |
Abbott Laboratories | Assay Description For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(... | J Med Chem 48: 5295-304 (2005) Article DOI: 10.1021/jm050205o BindingDB Entry DOI: 10.7270/Q21C1V5P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucocorticoid (RAT) | BDBM19238![]() (2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 8.0 | 4 |
Abbott Laboratories | Assay Description For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the... | J Med Chem 48: 5295-304 (2005) Article DOI: 10.1021/jm050205o BindingDB Entry DOI: 10.7270/Q21C1V5P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mineralocorticoid receptor (Homo sapiens (Human)) | BDBM19238![]() (2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | 8.0 | 4 |
Abbott Laboratories | Assay Description For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the... | J Med Chem 48: 5295-304 (2005) Article DOI: 10.1021/jm050205o BindingDB Entry DOI: 10.7270/Q21C1V5P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Androgen Receptor (Homo sapiens (Human)) | BDBM19238![]() (2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | 8.0 | 4 |
Abbott Laboratories | Assay Description For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the... | J Med Chem 48: 5295-304 (2005) Article DOI: 10.1021/jm050205o BindingDB Entry DOI: 10.7270/Q21C1V5P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Progesterone receptor (Homo sapiens (Human)) | BDBM19238![]() (2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | 8.0 | 4 |
Abbott Laboratories | Assay Description For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the... | J Med Chem 48: 5295-304 (2005) Article DOI: 10.1021/jm050205o BindingDB Entry DOI: 10.7270/Q21C1V5P | |||||||||||
More data for this Ligand-Target Pair |