BDBM192404 US9187462, II-14

SMILES: COc1ccc(nc1)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1

InChI Key: InChIKey=GRWXYVACNOJJLZ-HSZRJFAPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 192404   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192404 (US9187462, II-14) Show SMILES COc1ccc(nc1)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 |r| Show InChI InChI=1S/C25H26FN7O3/c1-33-14-16(11-29-33)23(21-4-3-18(35-2)12-27-21)32-24(34)15-9-20(26)19-13-28-25(31-22(19)10-15)30-17-5-7-36-8-6-17/h3-4,9-14,17,23H,5-8H2,1-2H3,(H,32,34)(H,28,30,31)/t23-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	153	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc.; Genentech, Inc. US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair