BDBM192550 US9187486, 12

SMILES: N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(F)cc1F

InChI Key: InChIKey=HODYSLLYOCDDRP-HNNXBMFYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 192550   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM192550 (US9187486, 12) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(F)cc1F |r| Show InChI InChI=1S/C22H21F2N7/c23-14-3-5-17(18(24)10-14)19-6-4-16-11-27-22(31(16)29-19)28-20-12-26-8-7-21(20)30-9-1-2-15(25)13-30/h3-8,10-12,15H,1-2,9,13,25H2,(H,27,28)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9187486 (2015) BindingDB Entry DOI: 10.7270/Q24748NM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM192550 (US9187486, 12) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(F)cc1F |r| Show InChI InChI=1S/C22H21F2N7/c23-14-3-5-17(18(24)10-14)19-6-4-16-11-27-22(31(16)29-19)28-20-12-26-8-7-21(20)30-9-1-2-15(25)13-30/h3-8,10-12,15H,1-2,9,13,25H2,(H,27,28)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9187486 (2015) BindingDB Entry DOI: 10.7270/Q24748NM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PIM (Homo sapiens (Human))	BDBM192550 (US9187486, 12) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(F)cc1F |r| Show InChI InChI=1S/C22H21F2N7/c23-14-3-5-17(18(24)10-14)19-6-4-16-11-27-22(31(16)29-19)28-20-12-26-8-7-21(20)30-9-1-2-15(25)13-30/h3-8,10-12,15H,1-2,9,13,25H2,(H,27,28)/t15-/m0/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM192550 (US9187486, 12) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(F)cc1F |r| Show InChI InChI=1S/C22H21F2N7/c23-14-3-5-17(18(24)10-14)19-6-4-16-11-27-22(31(16)29-19)28-20-12-26-8-7-21(20)30-9-1-2-15(25)13-30/h3-8,10-12,15H,1-2,9,13,25H2,(H,27,28)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assay				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM192550 (US9187486, 12) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ccc(F)cc1F |r| Show InChI InChI=1S/C22H21F2N7/c23-14-3-5-17(18(24)10-14)19-6-4-16-11-27-22(31(16)29-19)28-20-12-26-8-7-21(20)30-9-1-2-15(25)13-30/h3-8,10-12,15H,1-2,9,13,25H2,(H,27,28)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
					More data for this Ligand-Target Pair