BDBM192615 US10526329, Compound 114::US9670204, 114 2-(4-(2-ethyl-3-((4-(4-fluorophenyl)thiazol-2-yl)(methyl)amino)imidazo[1,2-a]pyridin-6-yl)piperidin-1-yl)-N,N-dimethylacetamide

SMILES: CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC(=O)N(C)C)CC1

InChI Key: InChIKey=PUCCJLCVNUSFNE-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 192615   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192615 (US10526329, Compound 114 | US11072611, Compound 11...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C28H33FN6OS/c1-5-23-27(33(4)28-31-24(18-37-28)20-6-9-22(29)10-7-20)35-16-21(8-11-25(35)30-23)19-12-14-34(15-13-19)17-26(36)32(2)3/h6-11,16,18-19H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	8.5	25
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate. 5 μL of a di...				US Patent US9670204 (2017) BindingDB Entry DOI: 10.7270/Q2W66HZS
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192615 (US10526329, Compound 114 | US11072611, Compound 11...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C28H33FN6OS/c1-5-23-27(33(4)28-31-24(18-37-28)20-6-9-22(29)10-7-20)35-16-21(8-11-25(35)30-23)19-12-14-34(15-13-19)17-26(36)32(2)3/h6-11,16,18-19H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	261	n/a	n/a	n/a	n/a	n/a	n/a
Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France. Curated by ChEMBL					Assay Description Inhibition of glycosylated human ATX using LPC 16:0 as substrate after 30 mins by luminescence assay				J Med Chem 60: 7371-7392 (2017) Article DOI: 10.1021/acs.jmedchem.7b00647 BindingDB Entry DOI: 10.7270/Q2R213VZ
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Rattus norvegicus)	BDBM192615 (US10526329, Compound 114 | US11072611, Compound 11...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C28H33FN6OS/c1-5-23-27(33(4)28-31-24(18-37-28)20-6-9-22(29)10-7-20)35-16-21(8-11-25(35)30-23)19-12-14-34(15-13-19)17-26(36)32(2)3/h6-11,16,18-19H,5,12-15,17H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	476	n/a	n/a	n/a	n/a	n/a	n/a
Galapagos SASU , 102 Avenue Gaston Roussel, 93230 Romainville, France. Curated by ChEMBL					Assay Description Inhibition of ATX in rat plasma assessed as reduction in plasma lysophosphatidic acid 18:2 levels after 2 hrs by LC-MS/MS method				J Med Chem 60: 7371-7392 (2017) Article DOI: 10.1021/acs.jmedchem.7b00647 BindingDB Entry DOI: 10.7270/Q2R213VZ
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192615 (US10526329, Compound 114 | US11072611, Compound 11...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C28H33FN6OS/c1-5-23-27(33(4)28-31-24(18-37-28)20-6-9-22(29)10-7-20)35-16-21(8-11-25(35)30-23)19-12-14-34(15-13-19)17-26(36)32(2)3/h6-11,16,18-19H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192615 (US10526329, Compound 114 | US11072611, Compound 11...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C28H33FN6OS/c1-5-23-27(33(4)28-31-24(18-37-28)20-6-9-22(29)10-7-20)35-16-21(8-11-25(35)30-23)19-12-14-34(15-13-19)17-26(36)32(2)3/h6-11,16,18-19H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent									US Patent US10526329 (2020) BindingDB Entry DOI: 10.7270/Q2Z60RGR
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192615 (US10526329, Compound 114 | US11072611, Compound 11...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C28H33FN6OS/c1-5-23-27(33(4)28-31-24(18-37-28)20-6-9-22(29)10-7-20)35-16-21(8-11-25(35)30-23)19-12-14-34(15-13-19)17-26(36)32(2)3/h6-11,16,18-19H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192615 (US10526329, Compound 114 | US11072611, Compound 11...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)C1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C28H33FN6OS/c1-5-23-27(33(4)28-31-24(18-37-28)20-6-9-22(29)10-7-20)35-16-21(8-11-25(35)30-23)19-12-14-34(15-13-19)17-26(36)32(2)3/h6-11,16,18-19H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...				US Patent US10526329 (2020) BindingDB Entry DOI: 10.7270/Q2Z60RGR
					More data for this Ligand-Target Pair