BDBM192793 US9187487, 27

SMILES: CN(C)C(=O)C(=Cc1cccc(c1)-c1cnc2[nH]ccc2n1)C#N

InChI Key: InChIKey=XXZRACQANQDIAP-NTEUORMPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 192793   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
JAK3 (aa 781-1124) (Homo sapiens (Human))	BDBM192793 (US9187487, 27) Show SMILES CN(C)C(=O)C(=Cc1cccc(c1)-c1cnc2[nH]ccc2n1)C#N |w:6.6| Show InChI InChI=1S/C18H15N5O/c1-23(2)18(24)14(10-19)9-12-4-3-5-13(8-12)16-11-21-17-15(22-16)6-7-20-17/h3-9,11H,1-2H3,(H,20,21)/b14-9+	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	7.5	-248.15
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured...				US Patent US9187487 (2015) BindingDB Entry DOI: 10.7270/Q2K936B3
					More data for this Ligand-Target Pair