BDBM192822 US9187487, 89

SMILES: CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C4SC(=O)N(CCN)C4=O)cc3)nc12

InChI Key: InChIKey=DPLSGEWWEVZDQF-YBEGLDIGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 192822   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
JAK3 (aa 781-1124) (Homo sapiens (Human))	BDBM192822 (US9187487, 89) Show SMILES CC(C)(C)C(=O)c1c[nH]c2ncc(Nc3ccc(C=C4SC(=O)N(CCN)C4=O)cc3)nc12 |w:18.17| Show InChI InChI=1S/C23H24N6O3S/c1-23(2,3)19(30)15-11-25-20-18(15)28-17(12-26-20)27-14-6-4-13(5-7-14)10-16-21(31)29(9-8-24)22(32)33-16/h4-7,10-12H,8-9,24H2,1-3H3,(H,25,26)(H,27,28)/b16-10-	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	-248.15
PRINCIPIA BIOPHARMA, INC. US Patent					Assay Description Phosphorylation of the appropriate peptide substrate (fluorescently labeled Srctide) by recombinant JAK3 (catalytic domain, aa 781-1124) was measured...				US Patent US9187487 (2015) BindingDB Entry DOI: 10.7270/Q2K936B3
					More data for this Ligand-Target Pair