BDBM192989 US10526329, Compound 169::US9670204, 169 2-(4-(3-((4-(2-cyano-4-fluorophenyl)thiazol-2-yl)(methyl)amino)-2-ethylimidazo[1,2-a]pyridin-6-yl)piperazin-1-yl)-N-methylacetamide

SMILES: CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1C#N)N1CCN(CC(=O)NC)CC1

InChI Key: InChIKey=ZBWCCKDEPNMVJU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 192989   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192989 (US10526329, Compound 169 | US11072611, Compound 16...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1C#N)N1CCN(CC(=O)NC)CC1 Show InChI InChI=1S/C27H29FN8OS/c1-4-22-26(33(3)27-32-23(17-38-27)21-7-5-19(28)13-18(21)14-29)36-15-20(6-8-24(36)31-22)35-11-9-34(10-12-35)16-25(37)30-2/h5-8,13,15,17H,4,9-12,16H2,1-3H3,(H,30,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	8.5	25
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate. 5 μL of a di...				US Patent US9670204 (2017) BindingDB Entry DOI: 10.7270/Q2W66HZS
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192989 (US10526329, Compound 169 | US11072611, Compound 16...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1C#N)N1CCN(CC(=O)NC)CC1 Show InChI InChI=1S/C27H29FN8OS/c1-4-22-26(33(3)27-32-23(17-38-27)21-7-5-19(28)13-18(21)14-29)36-15-20(6-8-24(36)31-22)35-11-9-34(10-12-35)16-25(37)30-2/h5-8,13,15,17H,4,9-12,16H2,1-3H3,(H,30,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192989 (US10526329, Compound 169 | US11072611, Compound 16...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1C#N)N1CCN(CC(=O)NC)CC1 Show InChI InChI=1S/C27H29FN8OS/c1-4-22-26(33(3)27-32-23(17-38-27)21-7-5-19(28)13-18(21)14-29)36-15-20(6-8-24(36)31-22)35-11-9-34(10-12-35)16-25(37)30-2/h5-8,13,15,17H,4,9-12,16H2,1-3H3,(H,30,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...				US Patent US10526329 (2020) BindingDB Entry DOI: 10.7270/Q2Z60RGR
					More data for this Ligand-Target Pair