BindingDB logo
myBDB logout

null

SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@H]1Oc1ccccc1C(F)(F)F

InChI Key: InChIKey=KQZAACHYOMQSHM-DYESRHJHSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193014   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM193014
PNG
(US9193726, 2)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@H]1Oc1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H23F3N4O3/c1-15-13-29(14-28-15)18-9-10-19-23(33)30(11-12-31(19)22(18)32)17-6-4-8-21(17)34-20-7-3-2-5-16(20)24(25,26)27/h2-3,5,7,9-10,13-14,17,21H,4,6,8,11-12H2,1H3/t17-,21-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 300n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair