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SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc2cc(F)c(F)cc12

InChI Key: InChIKey=KJMUAFRVYAYNTQ-HYBUGGRVSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193015   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM193015
PNG
(US9193726, 3)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1cccc2cc(F)c(F)cc12
Show InChI InChI=1S/C26H22F2N4O3/c1-15-13-30(14-29-15)21-5-6-22-26(34)31(9-10-32(22)25(21)33)20-7-8-24(20)35-23-4-2-3-16-11-18(27)19(28)12-17(16)23/h2-6,11-14,20,24H,7-10H2,1H3/t20-,24-/m1/s1
PDB
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PC sid
UniChem

Similars
US Patent
n/an/a 60.6n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair