BDBM193031 US9193726, 19

SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@H]1CON=C1c1ccc(F)c(F)c1

InChI Key: InChIKey=QPTDJGQPTPWCLC-SFHVURJKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193031   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193031 (US9193726, 19) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@H]1CON=C1c1ccc(F)c(F)c1 |c:24| Show InChI InChI=1S/C21H17F2N5O3/c1-12-9-26(11-24-12)16-4-5-17-21(30)28(7-6-27(17)20(16)29)18-10-31-25-19(18)13-2-3-14(22)15(23)8-13/h2-5,8-9,11,18H,6-7,10H2,1H3/t18-/m0/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair