BDBM193032 US9193726, 20

SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H](C1)Oc1cccc(c1)C(F)(F)F

InChI Key: InChIKey=FNJNJVYJUKUIQM-IEBWSBKVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193032   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193032 (US9193726, 20) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H](C1)Oc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C24H23F3N4O3/c1-15-13-29(14-28-15)20-7-8-21-23(33)30(9-10-31(21)22(20)32)17-5-6-19(12-17)34-18-4-2-3-16(11-18)24(25,26)27/h2-4,7-8,11,13-14,17,19H,5-6,9-10,12H2,1H3/t17-,19-/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.36E+3	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
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