BDBM193034 US9193726, 22

SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@H]1C[C@@H](C1)Oc1ccccc1C(F)(F)F

InChI Key: InChIKey=AOJACIPJVMFUDR-WKILWMFISA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193034   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193034 (US9193726, 22) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@H]1C[C@@H](C1)Oc1ccccc1C(F)(F)F |wU:18.20,wD:20.25,(11.86,-6.76,;11.24,-5.36,;9.73,-5.04,;9.57,-3.5,;10.98,-2.88,;12.01,-4.02,;8.24,-2.73,;8.24,-1.19,;6.9,-.42,;5.57,-1.19,;4.24,-.42,;4.24,1.12,;2.9,-1.19,;2.9,-2.73,;4.24,-3.5,;5.57,-2.73,;6.9,-3.5,;6.9,-5.04,;1.57,-.42,;.08,-.82,;-.32,.66,;1.17,1.06,;-1.65,1.43,;-1.65,2.97,;-.32,3.74,;-.32,5.28,;-1.65,6.05,;-2.98,5.28,;-2.98,3.74,;-4.32,2.97,;-5.65,2.2,;-5.09,4.31,;-3.55,1.64,)| Show InChI InChI=1S/C23H21F3N4O3/c1-14-12-28(13-27-14)18-6-7-19-22(32)29(8-9-30(19)21(18)31)15-10-16(11-15)33-20-5-3-2-4-17(20)23(24,25)26/h2-7,12-13,15-16H,8-11H2,1H3/t15-,16-	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	789	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
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