BDBM193037 US9193726, 25

SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@@H]1Cc1cc(F)cc(F)c1

InChI Key: InChIKey=RPJNOQYNBJHDOW-YLJYHZDGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193037   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193037 (US9193726, 25) Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CCC[C@@H]1Cc1cc(F)cc(F)c1 Show InChI InChI=1S/C24H24F2N4O2/c1-15-13-28(14-27-15)21-5-6-22-24(32)29(7-8-30(22)23(21)31)20-4-2-3-17(20)9-16-10-18(25)12-19(26)11-16/h5-6,10-14,17,20H,2-4,7-9H2,1H3/t17-,20-/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	561	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair