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SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1ccc(F)c(Cl)c1C

InChI Key: InChIKey=RSIKXWDIYXMYKV-OXQOHEQNSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193048   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM193048
PNG
(US9193726, 36)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(CCn2c1=O)[C@@H]1CC[C@H]1Oc1ccc(F)c(Cl)c1C
Show InChI InChI=1S/C23H22ClFN4O3/c1-13-11-27(12-26-13)17-4-5-18-23(31)28(9-10-29(18)22(17)30)16-6-8-20(16)32-19-7-3-15(25)21(24)14(19)2/h3-5,7,11-12,16,20H,6,8-10H2,1-2H3/t16-,20-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
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PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 146n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair