BDBM193052 US9193726, 40

SMILES: CC(C)c1c(F)cccc1O[C@@H]1CC[C@H]1N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O

InChI Key: InChIKey=PHGDTTZHEJHGLG-WIYYLYMNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193052   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193052 (US9193726, 40) Show SMILES CC(C)c1c(F)cccc1O[C@@H]1CC[C@H]1N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H27FN4O3/c1-15(2)23-17(26)5-4-6-22(23)33-21-10-9-18(21)29-11-12-30-20(25(29)32)8-7-19(24(30)31)28-13-16(3)27-14-28/h4-8,13-15,18,21H,9-12H2,1-3H3/t18-,21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	153	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair