BDBM193062 US9193726, 50

SMILES: C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(c(F)c1F)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O

InChI Key: InChIKey=SSHGDNRWJAOECR-PNHOKKKMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193062   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM193062 (US9193726, 50) Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(c(F)c1F)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O Show InChI InChI=1S/C25H23F5N4O3/c1-13-11-32(12-31-13)17-5-6-18-24(36)33(9-10-34(18)23(17)35)14(2)19-7-8-20(37-19)15-3-4-16(25(28,29)30)22(27)21(15)26/h3-6,11-12,14,19-20H,7-10H2,1-2H3/t14-,19-,20+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...				US Patent US9193726 (2015) BindingDB Entry DOI: 10.7270/Q22B8WT7
					More data for this Ligand-Target Pair