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SMILES: Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)C(C)(F)F)CCn2c1=O

InChI Key: InChIKey=XWHQAIFSBVXPAI-SIKLNZKXSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193072   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM193072
PNG
(US9193726, 60)
Show SMILES Cc1cn(cn1)-c1ccc2C(=O)N(C[C@@H]3CC[C@@H](O3)c3ccc(cc3)C(C)(F)F)CCn2c1=O
Show InChI InChI=1S/C25H26F2N4O3/c1-16-13-30(15-28-16)20-8-9-21-23(32)29(11-12-31(21)24(20)33)14-19-7-10-22(34-19)17-3-5-18(6-4-17)25(2,26)27/h3-6,8-9,13,15,19,22H,7,10-12,14H2,1-2H3/t19-,22+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 73.3n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair