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SMILES: C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(s1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O

InChI Key: InChIKey=XQZUMERXJVPQIX-JCGIZDLHSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193083   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM193083
PNG
(US9193726, 71)
Show SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(s1)C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O
Show InChI InChI=1S/C23H23F3N4O3S/c1-13-11-28(12-27-13)15-3-4-16-22(32)29(9-10-30(16)21(15)31)14(2)17-5-6-18(33-17)19-7-8-20(34-19)23(24,25)26/h3-4,7-8,11-12,14,17-18H,5-6,9-10H2,1-2H3/t14-,17-,18+/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 52.4n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair