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SMILES: C[C@H]1Cn2c(ccc(-n3cnc(C)c3)c2=O)C(=O)N1C[C@H]1CC[C@H](O1)c1ccc(cc1)C(F)(F)F

InChI Key: InChIKey=JCSBOEWGZOIJQZ-NBCNXNJRSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 193085   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM193085
PNG
(US9193726, 73)
Show SMILES C[C@H]1Cn2c(ccc(-n3cnc(C)c3)c2=O)C(=O)N1C[C@H]1CC[C@H](O1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H25F3N4O3/c1-15-11-30(14-29-15)20-8-9-21-24(34)31(16(2)12-32(21)23(20)33)13-19-7-10-22(35-19)17-3-5-18(6-4-17)25(26,27)28/h3-6,8-9,11,14,16,19,22H,7,10,12-13H2,1-2H3/t16-,19+,22-/m0/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 19.8n/an/an/an/an/a37



Pfizer Inc.

US Patent


Assay Description
The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cel...

US Patent US9193726 (2015)


BindingDB Entry DOI: 10.7270/Q22B8WT7
More data for this
Ligand-Target Pair