BDBM19331 CHEMBL266063::N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(1H-indol-3-yl)ethyl]-4-[(4-methoxyphenyl)methyl]-4H-1,2,4-triazol-3-yl}ethyl]piperidine-4-carboxamide::Trisubstituted 1,2,4-Triazole, 39
SMILES: COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1
InChI Key: InChIKey=MUMIOCPFGKBWRY-MGBGTMOVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ghrelin receptor (Homo sapiens (Human)) | BDBM19331 (CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.300 | n/a | 3 | n/a | n/a | n/a | n/a |
CNRS | Assay Description Specific binding was determined by incubation of membranes from GHS-R1a transfected LLC cells with 125I-His9-ghrelin in the presence of increasing co... | J Med Chem 50: 5790-5806 (2007) Article DOI: 10.1021/jm0704550 BindingDB Entry DOI: 10.7270/Q2HD7SZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM19331 (CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
CNRS-Université Montpellier I Curated by ChEMBL | Assay Description Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization | Bioorg Med Chem Lett 18: 164-8 (2008) Article DOI: 10.1016/j.bmcl.2007.10.113 BindingDB Entry DOI: 10.7270/Q2HM586C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM19331 (CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a |
Universités Montpellier 1 Curated by ChEMBL | Assay Description Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level | J Med Chem 51: 689-93 (2008) Article DOI: 10.1021/jm701292s BindingDB Entry DOI: 10.7270/Q2N0168Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM19331 (CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-Université Montpellier I Curated by ChEMBL | Assay Description Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells | Bioorg Med Chem Lett 18: 164-8 (2008) Article DOI: 10.1016/j.bmcl.2007.10.113 BindingDB Entry DOI: 10.7270/Q2HM586C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM19331 (CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Universités Montpellier 1 Curated by ChEMBL | Assay Description Displacement of 125I-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells | J Med Chem 51: 689-93 (2008) Article DOI: 10.1021/jm701292s BindingDB Entry DOI: 10.7270/Q2N0168Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ghrelin receptor (Homo sapiens (Human)) | BDBM19331 (CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-Université Montpellier I Curated by ChEMBL | Assay Description Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization | Bioorg Med Chem Lett 18: 164-8 (2008) Article DOI: 10.1016/j.bmcl.2007.10.113 BindingDB Entry DOI: 10.7270/Q2HM586C | |||||||||||
More data for this Ligand-Target Pair |